Arthritis

Preclinical studies have been done for treating arthritis in non-human primates.  X-ray images showed that animals with collagen induced arthritis that were not treated had a considerable inflammation and enlargement of the wrist.  In contrast, the wrist diameter of NF‑κB decoy treated animals was the same as animals that did not have the disease.

The NF‑κB decoy has been used as part of an investigator-sponsored Phase I trial in Japan for the treatment of rheumatoid arthritis.  The product was injected directly into the synovial space of the treated patients, with the objective of inhibiting pro-inflammatory activity of fibroblast-like synoviocytes and other localized cells. 

In humans having established arthritis, treatment with NF‑κB decoy decreased the duration of morning stiffness and improved their range of motion.  They reported less pain and an overall improvement of their condition.